Reg. No. G0408 Act 36/1947 Namibia Reg. No. N-SR 0873

Indications:
Berenil® cures and prevents Redwater in cattle and cures biliary fever in dogs and horses. Prevents Asiatic (European) Redwater for 2 weeks and African Redwater for 4 weeks.

Warnings:

• N.B. Prepared Berenil® solution should be stored protected from direct sunlight in tightly closed glass containers (e.g. bottles and ground glass stoppers).
• Do not slaughter animals for human consumption within 21 days of last treatment.
• After overdosing or repeated dosing, toxic disturbances of the central nervous system may develop.
• Keep out of reach of children, uninformed persons and animals.
• Dogs must be injected strictly according to body mass at 1 ml / 10 kg. The prescribed dose should not be exceeded or repeated under any circumstances.
• Although this remedy has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

Directions for Use: Use only as directed.

Cattle and horses: Dissolve a packet of 2,36 g Berenil® granules (1,05 g active) in 12,5 ml water (or a packet of 23,6 g in 125 ml) water for injection. When dissolved inject according to the following table, the dose for all animals being 3,5 mg active ingredient/kg body mass. It is recommended that a total dose of 4,0 g active Berenil® should not be exceeded even in the case of heavier animals.

N.B. The prepared solution is stable for 14 days if stored in a cool place, for 5 days at a temperature of ± 20 ºC and for 3 days at 30 ºC. At temperatures of 50 ºC to 60 ºC the solution is stable for ± 24 hours.

Inject intramuscularly in horses and cattle or subcutaneously in cattle only.

Dogs: Dissolve a sachet of 2,36 g Berenil® granules in 25 ml water (or 23,6 g in 250 ml) water for injection. The recommended dosage is 1 ml of this solution per 10 kg body mass injected intramuscularly or subcutaneously. This dosage must not be exceeded. Inject only once.

If the animal does not recover after one injection consult a Veterinarian for further treatment.

Suggested uses of Berenil® in the prevention of Redwater:

1. Protection of susceptible cattle being moved through a Redwater area: Inject Berenil® at recommended dosage to prevent Asiatic (European) Redwater for 2 weeks and African Redwater for 4 weeks.
2. Controlling a Redwater outbreak in a cattle herd: Inject all cattle with Berenil® at recommended dosage. This should stop further cases of Redwater within 24 hours and cure affected animals if not terminally ill.
3. Protection of stud animals at shows where the immune state of the animals to Redwater is uncertain: Use Berenil® at recommended dosage to prevent Redwater for the periods as mentioned in number 1 above. Keeping the animals tick free reduces chances of Redwater transmission following these periods.
4. Routine treatment of cattle arriving at feedlots: The use of Berenil® in this case renders protection as explained in number 1 above. Cure of animals already affected by Redwater may be expected, provided they are not terminally ill. The control of ticks on cattle at time of arrival should be coupled to the process.
5. Vaccine warning: Until further information is forthcoming the use of Berenil® is contra-indicated in cases when vaccination against Redwater is envisaged. If Berenil® has been used to suppress a Redwater vaccine reaction, re-vaccination of the treated animals is necessary. If immunity to Asiatic Redwater is required, re-vaccination after 1 month is recommended. If immunity to African Redwater is required, re-vaccination after 2 months is recommended.

Storage Instructions:
Store prepared solution in a refrigerator. Protect from sunlight. The prepared solution is stable for 14 days if stored in a cool place, for 5 days at a temperature of ± 20 ºC and for 3 days at 30 ºC. At temperatures of 50 ºC to 60 ºC the solution is stable for ± 24 hours